Southwestern Illinois is a thriving economic hub where metropolitan access meets Midwestern ambition. Home to more than 685,000 residents and a workforce of roughly 275,000, the region generates over $19 billion annually across a range of prominent industry clusters. With its strategic location, diverse talent, and deep industrial roots, Southwestern Illinois is the kind of place where businesses don’t just start—they stay and grow.
Stretching across nine connected counties, Southwestern Illinois produced more than $29 billion in GDP in 2023, making it one of the most dynamic regional economies in the Midwest. Built on a strong foundation of innovation, infrastructure, and long-term investment, the region offers room for expansion, a skilled labor force, and a business climate designed for growth.
Anchoring the region’s strength is Scott Air Force Base in St. Clair County, which contributes an estimated $12.9 billion to the regional economy and supports nearly 40,000 full-time equivalent jobs. Together, these assets create a resilient, opportunity-rich environment for companies of all sizes.
Southwestern Illinois is home to a mix of Fortune 500 companies, long-standing manufacturers, and fast-growing innovators. Businesses in logistics, healthcare, defense, and technology thrive here because of the region’s central location, supportive business climate, and talented workforce.
Curious who’s leading the way? Explore the region’s employers and see why Southwestern Illinois is the place where companies grow and succeed.