Southwestern Illinois is right where you need to be. In the heart of the country and just minutes from downtown St. Louis, our region's prime location connects you to the people, places, and infrastructure that drive business forward. With access to road, rail, air, and river, you won’t just reach your market, you’ll reach it faster.
In Southwestern Illinois, geography is on your side. We are within a day’s drive of more than one-third of the U.S. population, including major metros like Chicago, Nashville, Indianapolis, Kansas City, and Memphis. With direct connections to I-55, I-64, I-70, and I-255, our region makes short-haul and long-haul shipping both practical and predictable. Whether you're moving products or people, everything is closer from here.
4 Class I Railroads
6 Intermodal Terminals
2nd-Largest Inland Port System in the U.S.
3 Regional and International Airports
Being just across the river from St. Louis gives Southwestern Illinois something special, as we boast big-city access with Illinois-based advantages. Companies here reap all the benefits of being near a major metropolitan area, including talent, culture, and connectivity, while also taking advantage of Southwestern Illinois’ development-ready land, business incentives, and cost savings. Strong cross-river collaboration ensures your location works for you, not against you.